The first four of the eight Champions League quarter-finalists will become known on March 11-12 as the last-16 second legs combine with the Cheltenham Festival to make for a thrilling sporting week.
But by Wednesday night, the English representation could be down from four clubs to just two because Arsenal FC and Manchester City both need to produce a minor miracle to keep their European hopes alive.
The opening legs of their ties had many similarities – both English teams lost 2-0 at home to one of the competition favourites and had a man sent off before an hour had been played, while there was at least one penalty in each game.
First up to try and scale the mountain are Arsenal, who travel to the home of holders Bayern Munich knowing a repeat of last season’s 2-0 win there at the same stage would on this occasion mean extra time rather than a heroic failure.
However, it’s a huge ask against the 2/1 favourites (BetVictor
) to retain the trophy as the Gunners will be without Jack Wilshere, Aaron Ramsey and their long-term injury victims including Theo Walcott, as well as goalkeeper Wojciech Szczesny who was sent off when conceding the Bayern penalty missed by David Alaba at the Emirates.
Thomas Muller of Bayern Munich (third right) celebrates with his team-mates after scoring the second goal during the UEFA Champions League last-16 first leg match against Arsenal at the Emirates Stadium on February 19 2014 (Getty Images)
Mesut Ozil missed from the spot for Arsenal as goals from Toni Kroos and Thomas Muller established Pep Guardiola’s side as overwhelming favourites to go through.
City also need to produce something spectacular if they are to keep alive their hopes of reaching the May 24 showdown in Lisbon, trailing by two goals when they kick off against Barcelona in the Nou Camp.
Martin Demichelis was the man sent off at the Etihad Stadium as Lionel Messi showed more aptitude from the penalty spot than Arsenal and Bayern put together, giving his side the lead before Dani Alves drilled in a late second goal.
Paris Saint-Germain, meanwhile, are as good as through to the quarter-finals already for they won 4-0 in their first leg away to Bayer Leverkusen, while Atletico Madrid made it a clean sweep of away victories to nil in the corresponding first-leg week when they triumphed 1-0 at AC Milan through a Diego Costa goal.
You can read our full previews and get our betting tips for each match by clicking on the games below where they appear in blue.
UEFA Champions League schedule 2013-14 (all kick-off times 19:45 GMT, first-leg score in brackets)