Liverpool v Real Madrid is by far the biggest match involving an English club on match day three of the 2014-15 UEFA Champions League group stage.
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As the halfway stage of the competition’s round-robin phase is reached, the back-to-back double-headers take place and Anfield is the venue for the first clash between the Reds and the defending European champions in Group B.
Brendan Rodgers’ side really need to take a few points from the six available against Real having lost 1-0 in Basel last time out, and their qualification prospects will be in serious jeopardy if the Swiss club take a sizeable haul from their two matches against Ludogorets Razgrad.
But these games may not be one-sided because Real Madrid, who are the 4/1 joint favourites with bookmaker bwin
to retain the title, struggled to a 2-1 victory in Razgrad, the Bulgarians having fought bravely without reward in their two matches so far on their debut at this stage of the Champions League.
Also playing on Wednesday October 22 are Arsenal, who got their first three points on the board when they won 4-1 against Galatasaray courtesy of Danny Welbeck’s first senior hat-trick.
Atletico Madrid defender Diego Godin (left) vies with Real Madrid forward Cristiano Ronaldo during the UEFA Champions League Final in Lisbon on May 24 2014 (Getty Images)
The Gunners will hope to gain ground on Group D leaders Borussia Dortmund during their double-header against Anderlecht, the first game taking place in Belgium, while the Germans are next in action against the Turkish side.
Manchester City are facing a struggle to reach the last 16 and will hope to boost their prospects over their two games with CSKA Moscow, against whom they won both contests during the equivalent phase of last season’s competition.
The Premier League champions will be hoping for a favour from Bayern Munich when they take on Roma, firstly in the Italian capital’s Olympic Stadium.
As for Chelsea, they took control of Group G when they won 1-0 away to Sporting Lisbon and will aim to take a big step towards qualification initially at home to Maribor.
Among the other highlights is Barcelona v Ajax, with the Spanish giants targeting a victory that would undo some of the damage done by their 3-2 defeat away to Paris Saint-Germain on match day two.
2014-15 UEFA Champions League fixtures schedule
October 21-22 – Match day 3
Tuesday October 21
17:00 CSKA Moscow v Manchester City
19:45 Roma v Bayern Munich
19:45 APOEL Nicosia v Paris Saint-Germain
19:45 Barcelona v Ajax
19:45 Chelsea v Maribor
19:45 Schalke v Sporting Lisbon
19:45 BATE Borisov v Shakhtar Donetsk
19:45 Porto v Athletic Bilbao
Wednesday October 22
19:45 Atletico Madrid v Malmo
19:45 Olympiakos v Juventus
19:45 Liverpool v Real Madrid
19:45 Ludogorets Razgrad v Basel
19:45 Bayer Leverkusen v Zenit St Petersburg
19:45 Monaco v Benfica
19:45 Anderlecht v Arsenal
19:45 Galatasaray v Borussia Dortmund
November 4-5 – Match day 4
November 25-26 – Match day 5
December 9-10 – Match day 6
December 15 – Last-16 draw
February 17-18 – Last-16 first leg
February 24-25 – Last-16 first leg
March 10-11 – Last-16 second leg
March 17-18 – Last-16 second leg
March 20 – Quarter-final draw
April 14-15 – Quarter-final first leg
April 21-22 – Quarter-final second leg
April 24 – Semi-final draw
May 5-6 – Semi-final first leg
May 12-13 – Semi-final second leg
June 6 – Champions League Final in Berlin