Real Madrid's Sergio Ramos lifts the Champions League trophy after their victory in the 2016 final against Atletico Madrid (credit: Getty Images)
Real Madrid are defending the trophy in the 2016-17 Champions League and will continue their quest for a 12th European crown when they face Napoli in the round of 16.
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Los Blancos are four ahead of AC Milan on the list of most prolific European champions having triumphed on penalties last season in the San Siro after a 1-1 draw, Cristiano Ronaldo netting the decisive spot-kick as Real inflicted Champions League Final heartbreak on their local rivals Atletico for the second time in three years.
That defeat was all the more galling for Diego Simeone’s side because they had knocked out favourites Barcelona and Bayern Munich in the two previous rounds, but at least Atletico have a more favourable tie to look forward to in this season’s last 16 as they take on German outsiders Bayer Leverkusen.
Heading the English contingent, at least as far as the bookmakers are concerned, are Manchester City, who reached the semi-finals for the first time in 2015-16 and now have two-time winning coach Pep Guardiola leading them into battle.
Pep Guardiola kisses the UEFA Champions League trophy (Getty Images)
City, who finished second in their group behind Guardiola’s former club and 7/2 (Paddy Power
) Champions League favourites Barcelona, will be happy with their draw as they take on Monaco.
Elsewhere, there are a couple of ties that pit very familiar rivals against each other once more and one of those includes Arsenal, who go up against Bayern Munich in the last 16 for the third time in five seasons having bowed out to the Germans on both previous occasions. The Gunners also lost 5-1 to Bayern in the group stage last term.
Also trying to end a hoodoo are Paris Saint-Germain, who have been knocked out by Barcelona in two of the previous four campaigns – although the French champions did record a group-stage win against the Catalan giants in September 2014.
Premier League champions Leicester City will view their tie against Europa League holders Sevilla as a winnable one, while the remainder of the draw consists of Juventus taking on Porto whose compatriots Benfica meet Borussia Dortmund, winners of their group ahead of Real Madrid.
2016-17 UEFA Champions League fixture schedule
February 14-22 – Round-of-16 first leg (all kick-off times 19:45 GMT)
Tuesday February 14
Wednesday February 15
Tuesday February 21
Wednesday February 22
March 7-15 – Round-of-16 second leg
Tuesday March 7
Arsenal vs Bayern Munich
Napoli vs Real Madrid
Wednesday March 8
Barcelona vs Paris Saint-Germain
Borussia Dortmund vs Benfica
Tuesday March 14
Juventus vs Porto
Leicester City vs Sevilla
Wednesday March 15
Atletico Madrid vs Bayer Leverkusen
Monaco vs Manchester City
March 17 – Draw for quarter-finals
April 11-12 – Quarter-finals first leg
April 18-19 – Quarter-finals second leg
April 21 – Draw for semi-finals
May 2-3 – Semi-finals first leg
May 9-10 – Semi-finals second leg
June 3 – Final at Millennium Stadium, Cardiff