Three teams are already through to the last 16 and a whole host more will aim to join them when match-day five of the Champions League group stage takes place on November 24-25.
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After three rounds of fixtures, Zenit St Petersburg were the only team still with a 100% record and that remains the case, the Russian champions having made it four out of four with a 2-0 victory away to Lyon.
Zenit are assured of their place in the knockout phase and the same applies to Real Madrid, whose 1-0 triumph at home to Paris Saint-Germain was enough to send them through with Malmo losing 4-0 away to Shakhtar Donetsk.
Manchester City's Vincent Kompany (left) jumps for a header with Juventus forward Alvaro Morata during the Champions League group-stage match on September 15 2015 (Getty Images)
The third qualifiers at this stage are Manchester City, who completed a back-to-back double over Sevilla when prevailing 3-1 in Spain and only their next opponents Juventus can now catch the Premier League leaders.
For the other English clubs, there are contrasting situations. Manchester United will be sure of progressing if they follow their 1-0 home triumph over CSKA Moscow with another Old Trafford success against PSV Eindhoven who beat them 2-1 in the Netherlands.
Chelsea, even though their domestic form has been so poor, will be expected to inflict a fifth straight Group G defeat on Maccabi Tel Aviv and can also advance with a game to spare if they do so and Dynamo Kiev fail to win away to Porto.
But for Arsenal, it’s looking bleak after their 5-1 thrashing away to Bayern Munich. If Olympiakos avoid defeat away to the Germans it’s game over for the Gunners.
Should Arsene Wenger’s side and Bayern both win on match-day five, Arsenal would need to win their final group match in Greece by two goals or better or 4-3, 5-4 etc to go through.
Bayern are the 11/4 favourites for the competition with bookmaker Paddy Power ahead of 10/3 Barcelona and one more point will be enough for both of those giants to confirm their place in the last 16, with the reigning champions’ next match being at home to Roma.
2015-16 UEFA Champions League schedule (kick-off times 19:45 GMT unless stated):
November 24-25 – Group stage match day 5
Tuesday November 24
17:00 BATE Borisov v Bayer Leverkusen
Barcelona v Roma
Arsenal v Dinamo Zagreb
Bayern Munich v Olympiakos
Maccabi Tel Aviv v Chelsea
Porto v Dynamo Kiev
17:00 Zenit St Petersburg v Valencia
Lyon v Gent
Wednesday November 25
Malmo v Paris Saint-Germain
Shakhtar Donetsk v Real Madrid
17:00 CSKA Moscow v Wolfsburg
Manchester United v PSV Eindhoven
15:00 Astana v Benfica
Atletico Madrid v Galatasaray
Borussia Monchengladbach v Sevilla
Juventus v Manchester City